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1-C75.3), and Hodgkin lymphoma (ICD-O-3 histology codes 9650-9669, excluding Site Codes C70-C72, C75.1-C75.3). Please see Table?Table11 for the total number of deaths in 2009 due to each of these causes. Mortality and incidence rates per 100,000 population for each histology group were also calculated from the SEER dataset. Table 1 Demographics for persons 0�C19?years old who died of selected neoplastic histologies in 2009 (NVSS and SEER) YLLD was defined as the difference between age at diagnosis and age of death for those who die of cancer before 20?years of age. selleck chemicals llc Total YLLD was the sum of survival years for each person in the dataset, and mean YLLD was estimated by dividing total YLLD by number of deaths. All analyses were completed using R version 3.1.1 11 and SEER*Stat 8.1.5 12. All age-adjusted rates that were included have been adjusted to the 2000 U.S. standard population. Results There were a total of 48,259 deaths in children neoplasms (Table?(Table1).1). Within the SEER dataset, there were 547 deaths (��25% of NVSS). These deaths more commonly occurred ankyrin in males and white non-Hispanics. CNS tumors, leukemia, and lymphoma accounted for ��61% of total deaths due to cancer in 2009. The largest proportion of deaths occurred in children ages 15�C19?years, largely due to leukemia. For children who died at ages 0�C4?years, CNS tumors (including tumors of the brain, spine, or other CNS locations) caused ��31% of all deaths as compared to 43.1% of those in children ages 5�C9?years (Table?(Table2).2). Mean YPLL were not significantly different between the NVSS and SEER populations (Table?(Table22). Table 2 Total and mean YPLL (with median age at death) for persons 0�C19?years old who died of selected neoplastic histologies in 2009 overall and by 5-year age at death groups The age-adjusted mortality Selleckchem GSK-3 inhibitor rates for each of the four disease groups (CNS tumors, leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma) were similar in both datasets in 2009 (Fig.?(Fig.2A)2A) with CNS tumors having the?highest age-adjusted mortality rate (NVSS: CNS?=?8.1 per 1,000,000; leukemia?=?6.9 per 1,000,000; Hodgkin lymphoma?=?0.3 per 1,000,000; non-Hodgkin lymphoma =?0.9 per 1,000,000). CNS tumors also had the highest AAIR in 2009 (AAIR?=?5.2, 95% CI?=?4.8�C5.4), with leukemia having the second highest AAIR (AAIR?=?4.5, 95% CI?=?4.3�C4.8) (Fig.?(Fig.2B).2B). In both datasets, approximately 30% of deaths were attributed to CNS tumors, ��25% to leukemia, ��3% to non-Hodgkin lymphoma, and ��1% due to Hodgkin lymphoma (Fig.?(Fig.2C).2C). There were a total of 153,390.4 YPLL due to neoplasms in 2009 (Table?(Table2),2), representing 4.4% of a total 3,489,798.0 YPLL due to all causes in individuals