Since mTOR signaling pathway is involved in synaptogenesis, another possible side effect of rapamycin may be its impact on cognitive function

Physique excess weight monitoring shown that remedy with rapamycin at one. and 3. mg/kg reduced body excess weight The latter selection is labor-intense simply because the ninety six-well plates containing the chromatography fractions need to be sent to a microplate reader, hence generating this method incompatible with the HPLC autosampler significantly as compared to handle rats three weeks following remedy. B. Rats have been sacrificed after 4 months of treatment and the ratio of spleen to body weight was calculated. Rats handled with one. and three. mg/kg exhibited the ratio decrease. C. Rats were sacrificed following 4 months of treatment and the ratio of thymus to entire body fat was calculated. A reduced ratio was also found in rats dealt with with one. and three. mg/kg rapamycin. p