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Four race/ethnicity categories for both men and women were included in the final analysis: (1) NHW, (2) NHB, (3) Hispanic, and (4) API. AI/AN and cases with unknown race were excluded from the study due to small numbers, accounting for 0.25% and less than 1% of the total cases, respectively. 2.3. Statistical Analysis Age-adjusted incidence rates (all ages included) and stage-specific age-adjusted incidence rates (ages �� 50 only) per 100,000 were computed by subsite (all CRC, proximal, distal, rectum), sex (men, women), race/ethnicity DNA Synthesis inhibitor (NHW, NHB, Hispanic, API), and census-tract poverty categories. Only invasive cases were used to calculate the overall incidence rates to conform to standard population-based cancer incidence statistics in the USA, while incidence rates by stage included both invasive and in situ cases. The 2000 US standard population was used for age-adjustment of the rates. Incidence rate ratios (IRRs) were calculated for each of the three higher poverty categories versus the lowest poverty category. Confidence intervals (CIs) for incidence rates and IRRs were computed at the 95% level using the Tiwari et al. method, and the level of significance (alpha) was set at 0.05 (5%) for all statistical tests. Difference in the late-to-early stage rate ratios by poverty categories were tested with the 2-tailed z-statistic. For all analyses, we considered P values YES1 Volasertib using SEERStat software [21]. 3. Results The study population included 254,706 invasive CRC cases (all ages) and 223,015 invasive and in situ cases among persons aged 50 and older, diagnosed from 2005 to 2009. Proximal colon cases accounted for 42% of all CRCs; the distal colon, 24%; and the rectum, 28%. Among those aged 50+, the percentages of CRC by stage at diagnosis were 6% in situ, 38% localized, 31% regional, 17% distant, and 8% unknown. About 23% of the CRC cases were in the lowest poverty category (