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The large open dots in Figure 6A are the levels at which sleep perception occurred 50% (D50) and 80% (D80) of the time. Figure 6B shows the average ��ORPINT and average perception frequency in individual patients superimposed on the overall response. In most patients, the results were very close to the overall response. However, in eight patients, perception frequency was well below the overall response. Similar analysis for the different contributors to the integral indicated that D50 and D80 for time ORP was ATP7A D50 and D80 were 1.5 and 2.5 minutes, while any time ORP was NU7441 solubility dmso documentation of the time course of ORP during MSLT naps may a) provide information about the likelihood of loss of vigilance in the presence of normal environmental stimuli; b) serve as a quality control instrument; and c) when combined with assessment of sleep perception following the naps, could identify patients with impaired sleep /www.selleckchem.com/screening/anti-infection-compound-library.html perception. In addition, nearly half the patients met the criteria of idiopathic hypersomnia (IH). As a result, this study provided new insights into this disorder, including poor nocturnal sleep quality, maximum sleepiness in mid-morning, and considerable variability in the depth of sleep reached during naps even when average SOL is very short. Relation between ORP and sleep/wakefulness state In a validation study in which two experienced technologists scored each of 44,274 30-second epochs,5 it was shown that when ORP was >2.25, epochs were invariably scored awake. Between 2.25 and 2.0, brief sleep periods began to appear, but they did not add up to the requisite 15 seconds/epoch. As a result, epochs with ORP >2.0 were scored awake by at least one scorer 99% of the time and by both scorers in 95% of cases. As ORP decreased