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89, p?Ritonavir strong correlations of the skeletal muscle SEPI during exercise and tissue pH time courses and of post exercise SEPI and parameters of energy metabolism were observed. In conclusion, a tight coupling between skeletal muscle metabolic activity and tissue signal weighting, probably induced by osmotically driven water shift, exists and can be measured non-invasively, using NMR at 7?T. ? 2014 The Authors. NMR in Biomedicine published by John Wiley & Sons, Ltd. ""A new pulse sequence based on intermolecular double-quantum coherences was proposed to obtain one-dimensional high-resolution liquid NMR spectra in inhomogeneous magnetic fields via Hadamard encoding. In contrast with the conventional intermolecular multiple-quantum coherences method with a two-dimensional acquisition to obtain one one-dimensional high-resolution spectrum, the new method can provide relatively high-resolution spectra directly through one-dimensional acquisition, and can greatly improve the signal-to-noise ratio of the spectrum within a relatively short acquisition time. Theoretical derivation was performed SCH772984 and analytical expressions of the resulting signals are given. Solution samples in purposely de-shimmed magnetic fields and pig brain tissue samples were tested. The experimental results demonstrate that this sequence can retain useful structural information, even when Dabrafenib datasheet the field inhomogeneity is sufficiently severe to erase almost all spectral information with conventional one-dimensional single-quantum coherence techniques, and good solvent suppression can be achieved. This method may provide a promising technique for applications in in vivo and in vitro NMR. Copyright ? 2012 John Wiley & Sons, Ltd. ""Diffusion NMR is a powerful tool for gleaning microstructural information on opaque systems. In this work, the signal decay in single-pulsed-field gradient diffusion NMR experiments performed on a series of phantoms of increasing complexity, where the ground truth is known a priori, was modeled and used to identify microstructural features of these complex phantoms. We were able to demonstrate that, without assuming the number of components or compartments, the modeling can identify the number of restricted components, detect their sizes with an accuracy of a fraction of a micrometer, determine their relative populations, and identify and characterize free diffusion when present in addition to the components exhibiting restricted diffusion. After the accuracy of the modeling had been demonstrated, this same approach was used to study fixed nerves under different experimental conditions.