Historically, the first person to link IOP to the glaucoma was the English ophthalmologist, Richard Bannister, who described the phenomenon

In open angle glaucoma (OAG) the drainage pathway seems standard and in angle-closure glaucoma (ACG) the drainage pathway is obstructed. The pathogenesis of glaucoma is multifactorial. Nonetheless, the intra ocular force (IOP) is the most obvious danger issue for glaucomatous harm and to date IOP lowering medicines continue to be the only clinically validated treatment method of glaucoma [4,5]. Historically, the very first particular person to link IOP to the glaucoma was the English ophthalmologist, Richard Bannister, who described the phenomenon in 1622[six]. In1862 it was recognized that the extract from the calabar bean could counteract mydriasis, and in 1876 pilocarpin was launched. The improvement of stress decreasing drugs accelerated in 1978 with the approval of Timolol[6]. In addition to glaucoma medication, glaucoma medical procedures has been done considering that 1856 when Albrecht von Graefe launched iridectomy. Hundred a long time later on the most widespread glaucoma surgical procedure, trabeculectomy, was developed[seven,8]. In spite of the advancement of a lot more surgical procedures the considerably most predominant treatment method of glaucoma is stress decreasing eye drops. The prevalence of glaucoma has been described in numerous research and important ethnic and geographic differences have been located. In spite of the special possibility to estimate the prevalence of glaucoma in the complete populace in Denmark only a few epidemiologic scientific studies have been performed. To our expertise the 1st research to estimate the variety of glaucoma patients in Denmark was executed in 1989. This research was based on a countrywide consumption of anti-glaucomatous medicines and exposed a prevalence of .76% in the age team earlier mentioned 40 a long time [9]. A stick to up of this review was executed in 2000 primarily based on a questionnaire study among personal follow ophthalmologists in Denmark. In this review the prevalence in Denmark was approximated to .65% in the whole populace[10]. A current review focused on the annual fees of glaucoma in Denmark and unveiled an incidence fee of 1.2 for each 1000 grown ups in the period from 2002 to 2007[eleven]. To our information no previous research has benefited from a full data sample from an whole populace to estimate the incidence and prevalence of glaucoma. Therefore, the purpose of the research was to explain the incidence and prevalence of glaucoma in the Danish inhabitants all through a fifteen-12 months interval. Moreover, we wished to examine the geographic variation of glaucoma in Denmark and characterize the utilization sample of glaucoma medication in the aforementioned period of time.The study populace comprised all people residing in Denmark in the time period from 1996 to 2011. The federal government financed healthcare program requests all pharmacies in Denmark to sign up all prescriptions at an personal amount by the so-called CPR-amount. Also, the Danish Countrywide Registry of Clients has collected discharge diagnoses from public and non-public hospitals in Denmark considering that 1977. From 1995 the registry has utilized diagnoses as coded in the ICD-ten. Data on glaucoma medication was attained from the Danish Registry of Medicinal Item Figures. Subsequent prescriptions had been regarded as glaucoma medicine (ATCcodes: S01ED01-05 = -blockers S01EE = prostaglandin analogs S01EA = 2-adrenergic agonists, S01EB = parasympathomimetic medication, S01EC = carbon anhydrase inhibitors S01EA51, S01EB51, S01ED51 = set mix medication). Glaucoma was defined as a problem handled as glaucoma. Individuals had been categorised as "incident" by the time of their initial prescription of glaucoma treatment. Clients have been categorized in accordance to their amount of therapy adjustments. A treatment method alter was outlined as the start of a glaucoma treatment with a lot more than a hundred and eighty-day time-smart gap among two purchases of glaucoma medication.Incidence charges had been calculated in ten-yr age strata. As earlier pointed out, patients have been categorised as "incident" by the time of their first prescription of glaucoma treatment.