Inflammation exacerbates dopamine neuron degeneration in vivo caused by a-synuclein overexpression

Representative photomicrographs indicate the Nurr1 agonist induced a protecting affect on TH +ve (brown) and NeuN +ve (gray) neurons within the SNpc and TH +ve fibers in the All processes ended up accepted by the University of Tuebingen Institutional Animal Treatment and Use Committee striatum (C). Rats experienced a significant sparing of dopaminergic neurons in the SNpc following 32 times of therapy with the compound, in contrast to car remedy (D). Dopamine neuron fibers in the rostral striatum have been also significantly spared with Nurr1 agonist remedy when compared to vehicle treatment method (E). Significance is annotated as p